BDBM50388914 CHEMBL2063274::US10357546, p-OH SB-3CT

SMILES Oc1ccc(Oc2ccc(cc2)S(=O)(=O)CC2CS2)cc1

InChI Key InChIKey=AHDPJKYOQXMDIX-UHFFFAOYSA-N

Data  13 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50388914   

Target72 kDa type IV collagenase(Human)
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50388914(CHEMBL2063274 | US10357546, p-OH SB-3CT)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant MMP-2 using MOCAcPLGLA2pr(Dnp)AR-NH2 as substrate by fluorescence spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50388914(CHEMBL2063274 | US10357546, p-OH SB-3CT)
Affinity DataKi:  6nMAssay Description:Competitive inhibition of human MMP2 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50388914(CHEMBL2063274 | US10357546, p-OH SB-3CT)
Affinity DataKi:  6nMAssay Description:Inhibition of recombinant human MMP2 expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50388914(CHEMBL2063274 | US10357546, p-OH SB-3CT)
Affinity DataKi:  6nMAssay Description:Competitive inhibition of human MMP-2 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMatrix metalloproteinase-14(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50388914(CHEMBL2063274 | US10357546, p-OH SB-3CT)
Affinity DataKi:  90nMAssay Description:Competitive inhibition of human MMP14 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50388914(CHEMBL2063274 | US10357546, p-OH SB-3CT)
Affinity DataKi:  160nMAssay Description:Competitive inhibition of human MMP9 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
University of Notre Dame Du Lac

US Patent
LigandPNGBDBM50388914(CHEMBL2063274 | US10357546, p-OH SB-3CT)
Affinity DataKi:  160nMAssay Description:Human recombinant active MMP-2 and MMP-7, and the catalytic domains of MMP-3 and MMP-14/MT1-MMP were purchased from EMD Chemicals, Inc. (San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50388914(CHEMBL2063274 | US10357546, p-OH SB-3CT)
Affinity DataKi:  160nMAssay Description:Inhibition of recombinant human MMP9 expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50388914(CHEMBL2063274 | US10357546, p-OH SB-3CT)
Affinity DataKi:  160nMAssay Description:Competitive inhibition of human MMP-9 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetStromelysin-1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50388914(CHEMBL2063274 | US10357546, p-OH SB-3CT)
Affinity DataKi:  2.20E+3nMAssay Description:Competitive inhibition of human MMP3 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50388914(CHEMBL2063274 | US10357546, p-OH SB-3CT)
Affinity DataKi:  2.60E+3nMAssay Description:Human recombinant active MMP-2 and MMP-7, and the catalytic domains of MMP-3 and MMP-14/MT1-MMP were purchased from EMD Chemicals, Inc. (San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetMatrilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50388914(CHEMBL2063274 | US10357546, p-OH SB-3CT)
Affinity DataKi:  3.10E+4nMAssay Description:Competitive inhibition of human MMP7 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50388914(CHEMBL2063274 | US10357546, p-OH SB-3CT)
Affinity DataKi:  1.28E+5nMAssay Description:Competitive inhibition of human MMP1 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed