BDBM50388722 CHEMBL2059865

SMILES Cc1ccc(cc1NC(=O)c1ccc(OCc2ccccn2)cc1)-c1ncc[nH]1

InChI Key InChIKey=KMSKKYBHDQYHMC-UHFFFAOYSA-N

Data  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50388722   

TargetSmoothened homolog(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50388722(CHEMBL2059865)
Affinity DataEC50:  13nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50388722(CHEMBL2059865)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50388722(CHEMBL2059865)
Affinity DataEC50:  13nMAssay Description:Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50388722(CHEMBL2059865)
Affinity DataEC50:  130nMAssay Description:Displacement of BODIPY-labeled cyclopamine from human SMO transfected in human HeLa cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50388722(CHEMBL2059865)
Affinity DataEC50:  18nMAssay Description:Displacement of BODIPY-labeled cyclopamine from mouse SMO transfected in human HeLa cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50388722(CHEMBL2059865)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of SMO-mediated hedgehog signalling pathway in human HPEM cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed