BDBM50388105 CHEMBL2058169

SMILES Nc1ncc(cn1)-c1cn2cc(nc2c(n1)N1CCOCC1)C(=O)NCCN1CCOCC1

InChI Key InChIKey=YRCSAIYINRCQAV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50388105   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50388105(CHEMBL2058169)
Affinity DataIC50: 34.3nMAssay Description:Inhibition of PI3Kalpha-mediated AKT phosphorylation at Ser473 in human U2OS cells by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50388105(CHEMBL2058169)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50388105(CHEMBL2058169)
Affinity DataIC50: 10.4nMAssay Description:Inhibition of PI3Kalpha assessed as accumulation of ADPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed