BDBM503874 US11034692, Compound 157::US11034692, Compound 193::US11034692, Compound 212::trans-N-[8-amino-6-(4-methyl-3-pyridyl)- 2,7-naphthyridin-3-yl]-2- (cyanomethyl)cyclopropanecarboxamide

SMILES Cc1ccncc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3CC#N)ncc2c(N)n1

InChI Key InChIKey=RMLYABSTCHKDKH-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 503874   

LigandPNGBDBM503874(US11034692, Compound 212 | trans-N-[8-amino-6-(4-m...)
Affinity DataKi:  0.135nMAssay Description:Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

LigandPNGBDBM503874(US11034692, Compound 212 | trans-N-[8-amino-6-(4-m...)
Affinity DataKi:  0.570nMAssay Description:Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

LigandPNGBDBM503874(US11034692, Compound 212 | trans-N-[8-amino-6-(4-m...)
Affinity DataKi:  0.685nMAssay Description:Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent