BDBM50387268 CHEMBL2048571

SMILES CC(C)[C@H](C[C@@H]([C@H](CN1CC(=O)N(CC1(C)C)c2ccccc2Cl)N)O)C(=O)NCC(C)(C)C(=O)N

InChI Key InChIKey=RBIIKVXVYVANCQ-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50387268   

TargetRenin(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50387268(CHEMBL2048571)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRenin(Crab-eating macaque)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50387268(CHEMBL2048571)
Affinity DataIC50: 7nMAssay Description:Inhibition of renin in cynomolgus monkey plasma after 1 hr by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRenin(Crab-eating macaque)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50387268(CHEMBL2048571)
Affinity DataIC50: 7nMAssay Description:Inhibition of renin in cynomolgus monkey plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRenin(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50387268(CHEMBL2048571)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human purified reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)