BDBM50387188 CHEMBL2048199

SMILES CCCCNC(=O)c1ccc(OC)c(CSc2nc3cc(F)ccc3n2CC(O)=O)c1

InChI Key InChIKey=PCMUEDIHLGLRQZ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50387188   

TargetCytochrome P450 2D6(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387188(CHEMBL2048199)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387188(CHEMBL2048199)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of CYP3A4 using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387188(CHEMBL2048199)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CYP3A4 using testosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387188(CHEMBL2048199)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387188(CHEMBL2048199)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]-PGD2 from human DP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387188(CHEMBL2048199)
Affinity DataIC50: 41nMAssay Description:Antagonist activity at human CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change after 10 mins by flow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387188(CHEMBL2048199)
Affinity DataIC50: 81nMAssay Description:Displacement of [3H]-PGD2 from human CRTh2 receptor expressed in HEK293 cells in presence of 0.5% human serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387188(CHEMBL2048199)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human CRTh2 receptor expressed in HEK293 cells assessed as inhibition of PGD2-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387188(CHEMBL2048199)
Affinity DataIC50: 16nMAssay Description:Displacement of [3H]-PGD2 from human CRTh2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed