BDBM50386453 CHEMBL2047540

SMILES Oc1ccc(CC(N=O)C(=O)NCCS)cc1Br

InChI Key InChIKey=DGIAMZHTWIDUTM-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50386453   

TargetHistone deacetylase 6(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386453(CHEMBL2047540)
Affinity DataIC50: 360nMAssay Description:Inhibition of human recombinant HDAC6 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386453(CHEMBL2047540)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human recombinant HDAC7 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386453(CHEMBL2047540)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human recombinant HDAC8 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386453(CHEMBL2047540)
Affinity DataIC50: 3.02E+4nMAssay Description:Inhibition of Bordetella sp. (strain FB188) N-terminus His-tagged HDAH expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386453(CHEMBL2047540)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386453(CHEMBL2047540)
Affinity DataIC50: 960nMAssay Description:Inhibition of recombinant full length C-terminal FLAG-tagged human HDAC6 expressed in baculovirus infected Sf9 cells using Boc-Lys(Ac)-AMC as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50386453(CHEMBL2047540)
Affinity DataIC50: 120nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC3 (1 to 428 residues)/N-terminal GST-tagged recombinant human NCoR2 (395 to 489 residues) c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50386453(CHEMBL2047540)
Affinity DataIC50: 210nMAssay Description:Inhibition of recombinant full length C-terminal FLAG-tagged human HDAC2 expressed in baculovirus infected Sf9 cells using Boc-Lys(Ac)-AMC as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386453(CHEMBL2047540)
Affinity DataIC50: 52nMAssay Description:Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 expressed in baculovirus infected Sf9 cells using Boc-Lys(Ac)-AMC as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed