BDBM50386429 CHEMBL2047537

SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4c(F)cnn34)C(=O)NCc3ccc(F)c(c3)C(F)(F)F)c2ccc1C(O)=O

InChI Key InChIKey=CZRLAOXITNZAJA-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50386429   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Human)
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386429(CHEMBL2047537)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human recombinant aggrecanase 1 using aggrecan-IGD as substrate measured after 15 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386429(CHEMBL2047537)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant MMP14 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMatrilysin(Human)
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386429(CHEMBL2047537)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant MMP7 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386429(CHEMBL2047537)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant MMP2 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386429(CHEMBL2047537)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human recombinant MMP3 using MCAArg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(DNP)-NH2 as substrate preincubated for 10 mins measured by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386429(CHEMBL2047537)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant MMP1 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386429(CHEMBL2047537)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant MMP8 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386429(CHEMBL2047537)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant MMP9 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386429(CHEMBL2047537)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant MMP12 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386429(CHEMBL2047537)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant MMP13 using MCA-Pro-Cha-Gly-Nva-His-Ala-Dpa-NH2 as substrate preincubated for 10 mins measured by fluorescence analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386429(CHEMBL2047537)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant TACE using MCA-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 as substrate preincubated for 10 mins measured by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed