BDBM50385806 CHEMBL2041193

SMILES Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccc(cc1C)C(O)=O)c1ccncn1

InChI Key InChIKey=PHOCCMVBRLGOKP-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50385806   

TargetProlyl hydroxylase EGLN3(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PHD3 (unknown origin) expressed in Sf9 cells using HIF-1alpha peptide as substrate preincubated for 30 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetProlyl hydroxylase EGLN2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PHD1 (unknown origin) expressed in Sf9 cells using HIF-1alpha peptide as substrate preincubated for 30 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of FLAG-tagged full length PHD2 (unknown origin) expressed in Sf9 cells using HIF-1alpha peptide as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetProlyl hydroxylase EGLN3(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetProlyl hydroxylase EGLN2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Affinity DataIC50: 2.20E+4nMAssay Description:Binding affinity to human ErgMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Cav1.2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetProlyl hydroxylase EGLN3(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of FLAG- tagged full length HIF-PHD3 (unknown origin) expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProlyl hydroxylase EGLN2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of FLAG- tagged full length HIF-PHD1 (unknown origin) expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of FLAG- tagged full length HIF-PHD2 (unknown origin) expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed