BDBM50385302 CHEMBL2035461::US8592468, EbSe15

SMILES O=c1n(CCCn2[se]c3ccccc3c2=O)[se]c2ccccc12

InChI Key InChIKey=BCTQSAANYDAKPS-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50385302   

TargetThioredoxin reductase 1, cytoplasmic(Rat)
Peking University

Curated by ChEMBL
LigandPNGBDBM50385302(CHEMBL2035461 | US8592468, EbSe15)
Affinity DataIC50: 780nMAssay Description:Inhibition of TrxR1 in rat liver homogenate preincubated for 5 mins measured by DNTB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM50385302(CHEMBL2035461 | US8592468, EbSe15)
Affinity DataKi:  40nM IC50: 2.10E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2014
Entry Details
Go to US Patent