BDBM50384879 CHEMBL2035185

SMILES C(CN1CCCC1)Oc1ccc2Nc3nccc(n3)-c3ccc(COC\C=C\COCc1c2)o3

InChI Key InChIKey=NNXDIGHYPZHXTR-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50384879   

TargetCytochrome P450 1A2(Human)
S Bio

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CDK2 (unknown origin) by LANCE ULight TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 60nMAssay Description:Inhibition of FLT3 in human MV4-11 cells assessed as FLT3 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 46nMAssay Description:Inhibition of human JAK2 by western blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 69nMAssay Description:Inhibition of human CSF1R using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 69nMAssay Description:Inhibition of c-fmsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
S Bio

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 36nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
S Bio

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate by fluorescence detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
S Bio

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate by fluorescence detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
S Bio

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of recombinant CDK2 using RbING as substrate after 2 hrs by luminometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant FLT3 using poly(Glu,Tyr) as substrate after 2 hrs by luminometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
S Bio

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of recombinant JAK3 using poly(Glu,Ala,Tyr) as substrate after 2 hrs by luminometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant JAK2 using poly(Glu,Ala,Tyr) as substrate after 2 hrs by luminometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
S Bio

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of recombinant JAK1 using poly(Glu,Ala,Tyr) as substrate after 2 hrs by luminometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
S Bio

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using omeprazole as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
S Bio

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
S Bio

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 230nMAssay Description:Inhibition of TYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed