BDBM50384600 CHEMBL2036792::US9744172, Compound UNC00000563A

SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(cc1)N1CCNCC1

InChI Key InChIKey=ZICDFYRPBWSYAQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50384600   

LigandPNGBDBM50384600(CHEMBL2036792 | US9744172, Compound UNC00000563A)
Affinity DataIC50: 140nMAssay Description:Inhibition of Axl using KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50384600(CHEMBL2036792 | US9744172, Compound UNC00000563A)
Affinity DataIC50: 260nMAssay Description:Inhibition of Tyro3 using EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384600(CHEMBL2036792 | US9744172, Compound UNC00000563A)
Affinity DataIC50: 18nMAssay Description:Inhibition of Mer expressed in Escherichia coli BL21 (DE3) cells using EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluid capillary electr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384600(CHEMBL2036792 | US9744172, Compound UNC00000563A)
Affinity DataIC50: 55nMAssay Description:The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Mer(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384600(CHEMBL2036792 | US9744172, Compound UNC00000563A)
Affinity DataIC50: 18nMAssay Description:Inhibition of MER (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50384600(CHEMBL2036792 | US9744172, Compound UNC00000563A)
Affinity DataIC50: 14nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50384600(CHEMBL2036792 | US9744172, Compound UNC00000563A)
Affinity DataIC50: 199nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50384600(CHEMBL2036792 | US9744172, Compound UNC00000563A)
Affinity DataIC50: 114nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed