BDBM50384429 CHEMBL2031492::US9896452, Example 137

SMILES C[C@H]1CCCN([C@@H]1CNC(=O)c1cccc2cccnc12)C(=O)c1nc(C)sc1-c1ccccc1

InChI Key InChIKey=SRKVUFVTSRBFFN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50384429   

TargetOrexin receptor type 2(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50384429(CHEMBL2031492 | US9896452, Example 137)
Affinity DataIC50: 82nMAssay Description:Antagonist activity at OX2 receptor expressed in CHO cells assessed as inhibition of OXA-stimulated intracellular calcium mobilization after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50384429(CHEMBL2031492 | US9896452, Example 137)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at OX1 receptor expressed in CHO cells assessed as inhibition of OXA-stimulated intracellular calcium mobilization after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50384429(CHEMBL2031492 | US9896452, Example 137)
Affinity DataIC50: 3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO-OX1 or CHO-OX2 cells are seeded into black-walled clear-base 384-well plates (Costar) at a density of 20,00...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50384429(CHEMBL2031492 | US9896452, Example 137)
Affinity DataIC50: 100nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO-OX1 or CHO-OX2 cells are seeded into black-walled clear-base 384-well plates (Costar) at a density of 20,00...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent