BDBM50384427 CHEMBL2031490::US9896452, Example 139

SMILES Cc1nc(C(=O)N2CCC[C@H]([C@H]2CNC(=O)c2cccc3occc23)C(F)(F)F)c(s1)-c1ccccc1

InChI Key InChIKey=LHCWXNBUYBMDHF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50384427   

TargetOrexin receptor type 2(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50384427(CHEMBL2031490 | US9896452, Example 139)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at OX2 receptor expressed in CHO cells assessed as inhibition of OXA-stimulated intracellular calcium mobilization after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50384427(CHEMBL2031490 | US9896452, Example 139)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at OX1 receptor expressed in CHO cells assessed as inhibition of OXA-stimulated intracellular calcium mobilization after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50384427(CHEMBL2031490 | US9896452, Example 139)
Affinity DataIC50: 3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO-OX1 or CHO-OX2 cells are seeded into black-walled clear-base 384-well plates (Costar) at a density of 20,00...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50384427(CHEMBL2031490 | US9896452, Example 139)
Affinity DataIC50: 17nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO-OX1 or CHO-OX2 cells are seeded into black-walled clear-base 384-well plates (Costar) at a density of 20,00...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent