BDBM50384264 CHEMBL316966

SMILES c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@H]4[C@H](O3)CO[P@](=O)(O4)O)O)N

InChI Key InChIKey=IVOMOUWHDPKRLL-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50384264   

TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50384264(CHEMBL316966)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of EPAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50384264(CHEMBL316966)
Affinity DataIC50: 4.00E+4nMAssay Description:Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50384264(CHEMBL316966)
Affinity DataIC50: 4.80E+4nMAssay Description:Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50384264(CHEMBL316966)
Affinity DataKd:  4.50E+3nMAssay Description:Binding affinity to GST-tagged human EPAC1 CNBD (149 to 318 residues) expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by 8-NBD-cAMP ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed