BDBM50383715 CHEMBL2030376

SMILES c1cc2c(cc1Br)c3c(o2)C(=O)NC(=N3)CN4CC[C@@H](C4)O

InChI Key InChIKey=FRRLLRQAGKSVMU-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50383715   

LigandPNGBDBM50383715(CHEMBL2030376)
Affinity DataIC50: 1.47E+3nMAssay Description:Inhibition of CDC7 in human MDA-MB-231T cells assessed as inhibition of MCM2 phosphorylation at Ser53 after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50383715(CHEMBL2030376)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50383715(CHEMBL2030376)
Affinity DataIC50: 11nMAssay Description:Inhibition of N-terminus His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50383715(CHEMBL2030376)
Affinity DataIC50: 11nMAssay Description:Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50383715(CHEMBL2030376)
Affinity DataIC50: 121nMAssay Description:Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50383715(CHEMBL2030376)
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed