BDBM50383191 CHEMBL2031893

SMILES CC1=C(C(=O)N(N1C)c2ccccc2)C(=O)Nc3ccc(c(c3)F)Oc4ccnc5c4cc(c(c5)OC)OC

InChI Key InChIKey=SBLMCLDRWJNEJK-UHFFFAOYSA-N

Data  4 KI  36 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 40 hits for monomerid = 50383191   

TargetInsulin receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 10nMAssay Description:Inhibition of IRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 1nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase pim-2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of PIM2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of PIM1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of FGFRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKBalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 100nMAssay Description:Inhibition of c-KITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of PKBbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 10nMAssay Description:Inhibition of BTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 10nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 100nMAssay Description:Inhibition of TIE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 10nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 10nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of aurora-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 10nMAssay Description:Inhibition of VEGFR2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 20nMAssay Description:Inhibition of HGF-mediated c-met autophosphorylation in serum-starved human PC3 cells after 1 hr by electrochemiluminescent immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 1nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 5 activator 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CDK5/p25More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 10nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of aurora-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 10nMAssay Description:Inhibition of VEGFR2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 10nMAssay Description:Inhibition of IGF1R by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 20nMAssay Description:Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 10nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 1nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRibosomal protein S6 kinase beta-1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 10nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PKAalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MSK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataKi:  1nMAssay Description:Inhibition of RON by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataKi:  1nMAssay Description:Inhibition of RON by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant c-met-mediated gastrin phosphorylation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataKi:  32nMAssay Description:Inhibition of IGF1R by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed