BDBM50382545 CHEMBL2022247

SMILES Cc1cccc(C)c1-c1cccc(COc2ccc3C(CC(O)=O)COc3c2)c1

InChI Key InChIKey=CRHVDPHBIBYCLD-UHFFFAOYSA-N

Data  4 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50382545   

TargetFree fatty acid receptor 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50382545(CHEMBL2022247)
Affinity DataEC50:  38nMAssay Description:Agonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50382545(CHEMBL2022247)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50382545(CHEMBL2022247)
Affinity DataEC50:  27nMAssay Description:Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration after 90 secs by FLIPR ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50382545(CHEMBL2022247)
Affinity DataKi:  170nMAssay Description:Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membrane...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50382545(CHEMBL2022247)
Affinity DataKi:  170nMAssay Description:Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50382545(CHEMBL2022247)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50382545(CHEMBL2022247)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed