BDBM50382425 CHEMBL2022968::US20250026773, Positive Drug 2 TP0903

SMILES CN(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(CN3CCN(C)CC3)cc2)ncc1Cl

InChI Key InChIKey=YUAALFPUEOYPNX-UHFFFAOYSA-N

Data  5 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50382425   

TargetAurora kinase B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50382425(CHEMBL2022968 | US20250026773, Positive Drug 2 TP0...)
Affinity DataIC50: 12nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50382425(CHEMBL2022968 | US20250026773, Positive Drug 2 TP0...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50382425(CHEMBL2022968 | US20250026773, Positive Drug 2 TP0...)
Affinity DataEC50:  222nMAssay Description:Inhibition of AXL in human PSN1 cells assessed as decrease in GAS6-induced phospho-AXL level after 2 hrs by EILSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50382425(CHEMBL2022968 | US20250026773, Positive Drug 2 TP0...)
Affinity DataEC50:  305nMAssay Description:Inhibition of AXL-mediated AKT Ser473 phosphorylation in human PSN1 cells assessed as decrease in GAS6-induced phospho-AKT level after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAurora kinase A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50382425(CHEMBL2022968 | US20250026773, Positive Drug 2 TP0...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50382425(CHEMBL2022968 | US20250026773, Positive Drug 2 TP0...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human Axl using KKSRGDYMTMQIG as substrate incubated for 40 mins in the presence of [gamma33P]ATP by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM50382425(CHEMBL2022968 | US20250026773, Positive Drug 2 TP0...)
Affinity DataIC50: 16.4nMAssay Description:AXL enzyme (Carna, 08-107) configuration and addition: 33.33 ng/μL of AXL enzyme was diluted to 0.027 ng/μL (1.67×, final conc.=0.016 ng/μL) with 1× ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent