BDBM50381750 CHEMBL2022660

SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=Cc5c(C[C@]34C)cnn5-c3ccccc3)[C@@H]1CC[C@]2(O)C(=O)CSc1ccc2ccccc2n1

InChI Key InChIKey=HXOIEXFGROQJTJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50381750   

TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50381750(CHEMBL2022660)
Affinity DataIC50: 14.8nMAssay Description:Transrepression activity at glucocorticoid receptor in human H292 cells assessed as inhibition of TNF-induced IL8 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50381750(CHEMBL2022660)
Affinity DataIC50: 60.1nMAssay Description:Transactivation activity at glucocorticoid receptor in human HepG2 cells assessed as induction of tyrosine aminotransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50381750(CHEMBL2022660)
Affinity DataIC50: 82.3nMAssay Description:Transactivation activity at glucocorticoid receptor in rat H4II-E cells assessed as induction of tyrosine aminotransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50381750(CHEMBL2022660)
Affinity DataIC50: 101nMAssay Description:Transactivation activity at human glucocorticoid receptor in cells co-expressing GRE by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed