BDBM50380321 CHEMBL2017654

SMILES Fc1cc(ccc1-c1c(sc(N2CCOCC2)c1C#N)-c1nnc[nH]1)C#N

InChI Key InChIKey=MUENOTXSRZEFJV-UHFFFAOYSA-N

Data  2 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50380321   

LigandPNGBDBM50380321(CHEMBL2017654)
Affinity DataIC50: 79nMAssay Description:Inhibition of PI3Kalpha-mediated AKT phosphorylation at S473 by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50380321(CHEMBL2017654)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of His-tagged human full length PI3Kalpha coexpressed with p85 alpha in baculovirus expression system using PIP2 peptide as substrate incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50380321(CHEMBL2017654)
Affinity DataIC50: 124nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant full length PI3Kbeta co-expressed with human recombinant full length P85alpha in baculovirus i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50380321(CHEMBL2017654)
Affinity DataIC50: 60nMAssay Description:Inhibition of GST-tagged human recombinant PI3Kgamma catalytic domain (468 to 1203 residues) expressed in insect cells using PIP2 peptide as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50380321(CHEMBL2017654)
Affinity DataIC50: 4.06E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged human recombinant mTOR (1362 to end residues) using ULight-4E-BP1 (Thr37/46) peptide as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50380321(CHEMBL2017654)
Affinity DataIC50: 15nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant full length PI3Kdelta co-expressed with human recombinant full length P85alpha in baculovirus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50380321(CHEMBL2017654)
Affinity DataKi:  0.600nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50380321(CHEMBL2017654)
Affinity DataKi:  1.44E+3nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed