BDBM50379716 CHEMBL2011125

SMILES CC(C)N1Cc2c(nc(nc2NCc2cnc3ccccc3c2)N2CCN(CC2)C(C)=O)C1=O

InChI Key InChIKey=CTNRCYKVGGRNOG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50379716   

TargetP2X purinoceptor 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50379716(CHEMBL2011125)
Affinity DataIC50: 24nMAssay Description:Antagonist activity at human P2X3 expressed in rat liver endothelium cells assessed as inhibition of the intracellular calcium increase after 30 to 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50379716(CHEMBL2011125)
Affinity DataIC50: 24nMAssay Description:Antagonist activity at human P2X3 receptor expressed in RLE cells assessed as inhibition of (alpha,beta)me-ATP-induced intracellular calcium level by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50379716(CHEMBL2011125)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of recombinant CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed