BDBM50379227 CHEMBL2011293::US9416123, 7

SMILES Nc1c(c(nn1-c1ccc(Cl)cc1)-c1ccncc1)-c1ccc(F)cc1

InChI Key InChIKey=QJVWSZUUCBXFHW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50379227   

LigandPNGBDBM50379227(CHEMBL2011293 | US9416123, 7)
Affinity DataIC50: 1.20E+3nMpH: 7.5 T: 2°CAssay Description:FlashPlates from Perkin Elmer (Boston, Mass., USA) with a 50 μl reaction volume are used. The reaction cocktail was pipetted in 4 steps in the fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
Go to US Patent

LigandPNGBDBM50379227(CHEMBL2011293 | US9416123, 7)
Affinity DataIC50: 800nMpH: 7.5 T: 2°CAssay Description:FlashPlates from Perkin Elmer (Boston, Mass., USA) with a 50 μl reaction volume are used. The reaction cocktail was pipetted in 4 steps in the fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Synovo

US Patent
LigandPNGBDBM50379227(CHEMBL2011293 | US9416123, 7)
Affinity DataIC50: 2.30E+4nMpH: 7.5 T: 2°CAssay Description:FlashPlates from Perkin Elmer (Boston, Mass., USA) with a 50 μl reaction volume are used. The reaction cocktail was pipetted in 4 steps in the fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Synovo

US Patent
LigandPNGBDBM50379227(CHEMBL2011293 | US9416123, 7)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of SRC using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50379227(CHEMBL2011293 | US9416123, 7)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of VEGFR2 using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed