BDBM50379220 CHEMBL2011302::US9416123, 16

SMILES Nc1c(C(O)=O)c(nn1-c1c(Cl)cc(Cl)cc1Cl)-c1ccncc1

InChI Key InChIKey=ZZRPBQTWUXGZKR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50379220   

LigandPNGBDBM50379220(CHEMBL2011302 | US9416123, 16)
Affinity DataIC50: 4.30E+4nMpH: 7.5 T: 2°CAssay Description:FlashPlates from Perkin Elmer (Boston, Mass., USA) with a 50 μl reaction volume are used. The reaction cocktail was pipetted in 4 steps in the fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
Go to US Patent

LigandPNGBDBM50379220(CHEMBL2011302 | US9416123, 16)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:FlashPlates from Perkin Elmer (Boston, Mass., USA) with a 50 μl reaction volume are used. The reaction cocktail was pipetted in 4 steps in the fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Synovo

US Patent
LigandPNGBDBM50379220(CHEMBL2011302 | US9416123, 16)
Affinity DataIC50: 5.50E+4nMpH: 7.5 T: 2°CAssay Description:FlashPlates from Perkin Elmer (Boston, Mass., USA) with a 50 μl reaction volume are used. The reaction cocktail was pipetted in 4 steps in the fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Synovo

US Patent
LigandPNGBDBM50379220(CHEMBL2011302 | US9416123, 16)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of SRC using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50379220(CHEMBL2011302 | US9416123, 16)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of VEGFR2 using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed