BDBM50379146 CHEMBL2012829::US8703811, 31::US8703811, 32

SMILES Cc1nc2ccccc2n1-c1ccc(s1)C(=O)NC1CC1

InChI Key InChIKey=NDTLHRZTCBQAAJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50379146   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(malaria parasite P. falciparum)
Genzyme

US Patent
LigandPNGBDBM50379146(CHEMBL2012829 | US8703811, 31 | US8703811, 32)
Affinity DataIC50: 99nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(malaria parasite P. falciparum)
Genzyme

US Patent
LigandPNGBDBM50379146(CHEMBL2012829 | US8703811, 31 | US8703811, 32)
Affinity DataIC50: 74nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
Go to US Patent

LigandPNGBDBM50379146(CHEMBL2012829 | US8703811, 31 | US8703811, 32)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human DHODH after 20 mins by 2,6-dichloroindophenol-reduction based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed