BDBM50378146 CHEMBL1204009

SMILES CCOC(=O)CCc1ccc(OC[C@H](O)CNC(C)(C)Cc2ccc3ccccc3c2)c(c1)C#N

InChI Key InChIKey=HOWBDMROKCOABA-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50378146   

TargetBeta-2 adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50378146(CHEMBL1204009)
Affinity DataIC50: 14nMAssay Description:Inhibition of beta2 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50378146(CHEMBL1204009)
Affinity DataIC50: 0.0340nMAssay Description:Antagonist activity at human calcium receptor expressed in HEK293 4.0-7 cells assessed as inhibition of intracellular calcium release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50378146(CHEMBL1204009)
Affinity DataIC50: 0.00300nMAssay Description:Displacement of [3H](2-(2-hydroxyphenyl)-6-methyl-5-(2-methylpropyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone) from human calcium receptor expressed in h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50378146(CHEMBL1204009)
Affinity DataIC50: 37nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50378146(CHEMBL1204009)
Affinity DataIC50: 59nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50378146(CHEMBL1204009)
Affinity DataIC50: 78nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50378146(CHEMBL1204009)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50378146(CHEMBL1204009)
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed