BDBM50378006 CHEMBL1627316::US8748608, 42

SMILES OC(CCNC(=O)c1cc2ccccc2o1)CN1CCN(CC1)c1cccc(Cl)c1Cl

InChI Key InChIKey=DMQIMKFFQYYLKW-UHFFFAOYSA-N

Data  4 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50378006   

TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50378006(CHEMBL1627316 | US8748608, 42)
Affinity DataIC50: 13.7nMAssay Description:Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50378006(CHEMBL1627316 | US8748608, 42)
Affinity DataEC50:  22.8nMAssay Description:Agonist activity at human D3 receptor expressed in HEK293 cells assessed as stimulation of mitogenesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50378006(CHEMBL1627316 | US8748608, 42)
Affinity DataKi:  0.980nMAssay Description:Methods for performing in vitro dopamine receptor binding studies are described in Huang et al. J. Med. Chem. 44:1815-1826 (2001) and Luedtke et al. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2014
Entry Details
Go to US Patent

TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50378006(CHEMBL1627316 | US8748608, 42)
Affinity DataKi:  6.11nMAssay Description:Displacement of [125]IABN from human D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50378006(CHEMBL1627316 | US8748608, 42)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]SCH23390 from D1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50378006(CHEMBL1627316 | US8748608, 42)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125]IABN from human D4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2012
Entry Details Article
PubMed