BDBM50374731 CHEMBL260599

SMILES COc1cc2CCN(CC\C=C3/CCCc4c(OC)cccc34)Cc2cc1OC

InChI Key InChIKey=QBMVDXXIQASRIE-UHFFFAOYSA-N

Data  2 IC50  10 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50374731   

TargetMultidrug resistance-associated protein 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50374731(CHEMBL260599)
Affinity DataEC50:  2.80E+3nMAssay Description:Inhibition of MRP1 (unknown origin) over-expressed in MDCK cells assessed as calcein accumulation incubated for 30 mins prior to Calcein-AM addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50374731(CHEMBL260599)
Affinity DataEC50:  1.50E+3nMAssay Description:Inhibition of MDR1 (unknown origin) over-expressed in MDCK cells assessed as calcein accumulation incubated for 30 mins prior to Calcein-AM addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50374731(CHEMBL260599)
Affinity DataEC50:  820nMAssay Description:Activity at MDR1 (unknown origin) expressed in MDCK-MDR1 cells by Calcein-AM assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50374731(CHEMBL260599)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of MDR1 (unknown origin) expressed in MDCK cells after 30 mins by Calcein-AM assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50374731(CHEMBL260599)
Affinity DataEC50:  1.10E+3nMAssay Description:Activity at human MDR1 expressed in MDCK cells assessed as Calcein-AM uptake after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50374731(CHEMBL260599)
Affinity DataEC50:  2.80E+3nMAssay Description:Activity at MRP1 (unknown origin) expressed in MDCK cells assessed as interference calcein-AM efflux incubated for 30 mins prior to calcein-Am additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50374731(CHEMBL260599)
Affinity DataEC50:  1.50E+3nMAssay Description:Activity at MDR1 (unknown origin) expressed in MDCK cells assessed as interference with calcein-AM efflux incubated for 30 mins prior to calcein-Am a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50374731(CHEMBL260599)
Affinity DataEC50:  2.80E+3nMAssay Description:Activity at MRP1 (unknown origin) expressed in MDCK cells using calcein AM as substrate incubated for 30 mins prior to substrate addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50374731(CHEMBL260599)
Affinity DataEC50:  9.00E+4nMAssay Description:Activity at BCRP (unknown origin) expressed in MDCK cells using rhodamine 123 as substrate incubated for 30 mins prior to substrate addition measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50374731(CHEMBL260599)
Affinity DataEC50:  1.50E+3nMAssay Description:Activity at MDR1 (unknown origin) expressed in MDCK cells using calcein AM as substrate incubated for 30 mins prior to substrate addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50374731(CHEMBL260599)
Affinity DataEC50:  1.64E+3nMAssay Description:Inhibition of human Pgp mediated [3H]vinblastine transport in human Caco-2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50374731(CHEMBL260599)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as reduction in calcein-AM efflux preincubated for 30 mins followed by calcein-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed