BDBM50373215 CHEMBL259060

SMILES COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(cc1)S(C)(=O)=O

InChI Key InChIKey=WNTHBRVKPVTIQB-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50373215   

TargetMitogen-activated protein kinase 8(Rat)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50373215(CHEMBL259060)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of JNK1 in rat H9c2 cells assessed as inhibition of anisomycin-induced AP1 phosphorylation after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50373215(CHEMBL259060)
Affinity DataIC50: 34nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50373215(CHEMBL259060)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of p38 alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50373215(CHEMBL259060)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50373215(CHEMBL259060)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50373215(CHEMBL259060)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of TAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50373215(CHEMBL259060)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50373215(CHEMBL259060)
Affinity DataIC50: 30nMAssay Description:Inhibition of human JNK1 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50373215(CHEMBL259060)
Affinity DataIC50: 30nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50373215(CHEMBL259060)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of MEKKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Rat)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50373215(CHEMBL259060)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of JNK1 in rat H9c2 cells assessed as inhibition of anisomycin-induced cJun phosphorylation after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50373215(CHEMBL259060)
Affinity DataIC50: 30nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50373215(CHEMBL259060)
Affinity DataIC50: 30nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50373215(CHEMBL259060)
Affinity DataIC50: 30nMAssay Description:Inhibition of human JNK1 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50373215(CHEMBL259060)
Affinity DataIC50: 72nMAssay Description:Inhibition of human JNK2 alpha2 using GST-tagged ATF2 as substrate and [gamma33P]ATP incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50373215(CHEMBL259060)
Affinity DataIC50: 43nMAssay Description:Inhibition of human JNK1 alpha1 using GST-tagged ATF2 as substrate and [gamma33P]ATP incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed