BDBM50373192 CHEMBL405519::US10729710, Compound (I)::US20240352055, Compound (I)

SMILES CCCN1CCC[C@@H]2Cc3c(C[C@@H]12)ccc(O)c3O

InChI Key InChIKey=HZPDHOOVQQYBJP-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50373192   

TargetD(1A) dopamine receptor(Human)
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50373192(CHEMBL405519 | US10729710, Compound (I) | US202403...)
Affinity DataEC50:  25nMAssay Description:Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50373192(CHEMBL405519 | US10729710, Compound (I) | US202403...)
Affinity DataEC50:  0.650nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50373192(CHEMBL405519 | US10729710, Compound (I) | US202403...)
Affinity DataEC50:  3.30nMAssay Description:Dopamine D1 receptor agonism was measured using a HTRF cAMP from CisBio using the protocol developed by HD Biosciences (China). Briefly, the assay is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50373192(CHEMBL405519 | US10729710, Compound (I) | US202403...)
Affinity DataEC50:  1.30nMAssay Description:Dopamine D2 receptor agonism was measured using a calcium mobilization assay protocol developed by HD Biosciences (China). Briefly, HEK293/G15 cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2B(Mouse)
H. Lundbeck

US Patent
LigandPNGBDBM50373192(CHEMBL405519 | US10729710, Compound (I) | US202403...)
Affinity DataEC50:  2.90E+3nMAssay Description:Evaluation of the agonist activity of compounds (I), (Ia) and (Ib) at the human 5-HT2B receptor was performed by Eurofins/Cerep (France) measuring th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2B(Human)
H. Lundbeck

US Patent
LigandPNGBDBM50373192(CHEMBL405519 | US10729710, Compound (I) | US202403...)
Affinity DataEC50:  2.90E+3nMAssay Description:Evaluation of the affinity of compounds for the human 5-HT2B receptor was determined in a radioligand binding assay at Eurofins/Cerep (France). Membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
Go to US Patent