BDBM50373177 CHEMBL404038

SMILES c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[C@@H]4[C@@H]([C@H](O[C@H]4n5cnc6c5ncnc6N)CO[P@](=O)(O)O[C@@H]7[C@@H]([C@H](O[C@H]7n8cnc9c8ncnc9N)CO[P@](=O)(O)O[P@@](=O)(O)OP(=O)(O)O)O)O)O)O)N

InChI Key InChIKey=RTAGLZBJCCVJET-UHFFFAOYSA-N

Data  1 IC50  2 Kd  1 EC50

PDB links: 6 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50373177   

Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50373177(CHEMBL404038)
Affinity DataKd:  0.0400nMAssay Description:Binding affinity to human recombinant RNase LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50373177(CHEMBL404038)
Affinity DataEC50:  0.5nMAssay Description:Activation of human recombinant Rnase L assessed as cleavage of FRET RNA probeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50373177(CHEMBL404038)
Affinity DataKd:  0.220nMAssay Description:Displacement of 5'-phosphorylated, 2',5'-oligoadenylate from human recombinant RNase L assessed as decrease in resonance by surface plasma resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Mouse)
Gunma University

Curated by ChEMBL
LigandPNGBDBM50373177(CHEMBL404038)
Affinity DataIC50: 3nMAssay Description:Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed