BDBM50373059 CHEMBL429317

SMILES Cc1cc(on1)C(C=Nc1ccc(Cl)cc1)C(=O)Nc1ccc(Cl)cc1

InChI Key InChIKey=YFDGNBSGIOPFET-UHFFFAOYSA-N

Data  3 KI  3 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50373059   

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50373059(CHEMBL429317)
Affinity DataEC50:  700nMAssay Description:Activation of human alpha-7 nAChR expressed in Xenopus oocytes assessed as modulation of acetyl choline -induced current by two-electrode voltage-cla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50373059(CHEMBL429317)
Affinity DataEC50:  600nMAssay Description:Activation of human alpha-7 nAChR expressed in Xenopus oocytes assessed as modulation of choline-induced current by two-electrode voltage-clamp metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50373059(CHEMBL429317)
Affinity DataEC50:  500nMAssay Description:Activation of human alpha-7 nAChR expressed in Xenopus oocytes assessed as modulation of nicotine-induced current by two-electrode voltage-clamp meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of California

Curated by ChEMBL
LigandPNGBDBM50373059(CHEMBL429317)
Affinity DataIC50: 12nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha-7 nAChR in rat hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of California

Curated by ChEMBL
LigandPNGBDBM50373059(CHEMBL429317)
Affinity DataIC50: 28nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha-7 nAChR in rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50373059(CHEMBL429317)
Affinity DataEC50:  6.30E+3nMAssay Description:Activation of human GABAA alpha-2-beta-3-gamma-2L receptor expressed in Xenopus oocytes assessed as modulation of GABA-induced current by two-electro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of California

Curated by ChEMBL
LigandPNGBDBM50373059(CHEMBL429317)
Affinity DataIC50: 12nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha-7 nAChR in rat amygdalaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50373059(CHEMBL429317)
Affinity DataEC50:  700nMAssay Description:Positive allosteric modulation of human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in Ach-induced current at -90 mV membra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of California

Curated by ChEMBL
LigandPNGBDBM50373059(CHEMBL429317)
Affinity DataKi:  4.5nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha-7 nAChR in rat hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of California

Curated by ChEMBL
LigandPNGBDBM50373059(CHEMBL429317)
Affinity DataKi:  4.5nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha-7 nAChR in rat amygdalaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of California

Curated by ChEMBL
LigandPNGBDBM50373059(CHEMBL429317)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha-7 nAChR in rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed