BDBM50372473 CHEMBL270638

SMILES CC(C#N)c1ccc(cc1)-n1c(C)nc2cnc3ccc(cc3c12)C#Cc1cccnc1

InChI Key InChIKey=HFNJWNHCEQNJQQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50372473   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372473(CHEMBL270638)
Affinity DataIC50: 56nMAssay Description:Inhibition of PI3K p110alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372473(CHEMBL270638)
Affinity DataIC50: 446nMAssay Description:Inhibition of PI3K p110betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372473(CHEMBL270638)
Affinity DataIC50: 35nMAssay Description:Inhibition of PI3K p110deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372473(CHEMBL270638)
Affinity DataIC50: 117nMAssay Description:Inhibition of PI3K p110gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372473(CHEMBL270638)
Affinity DataIC50: 245nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372473(CHEMBL270638)
Affinity DataIC50: 45nMAssay Description:Inhibition of phosphorylation of T308-PKB in human U87MG cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed