BDBM50372472 CHEMBL255592

SMILES Cn1c2cnc3ccc(cc3c2n(-c2ccc(cc2)C(C)(C)C#N)c1=O)C#Cc1cccnc1

InChI Key InChIKey=ISHNPDWTQUXPSY-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50372472   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372472(CHEMBL255592)
Affinity DataIC50: 72nMAssay Description:Inhibition of PI3K p110alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372472(CHEMBL255592)
Affinity DataIC50: 2.34E+3nMAssay Description:Inhibition of PI3K p110betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372472(CHEMBL255592)
Affinity DataIC50: 201nMAssay Description:Inhibition of PI3K p110deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372472(CHEMBL255592)
Affinity DataIC50: 382nMAssay Description:Inhibition of PI3K p110gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372472(CHEMBL255592)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50372472(CHEMBL255592)
Affinity DataIC50: 33nMAssay Description:Inhibition of phosphorylation of T308-PKB in human U87MG cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed