BDBM50372181 CHEMBL403727

SMILES CCCN(CCC)C(=O)c1cc(C)cc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)Oc1ccccc1

InChI Key InChIKey=YDCNYSQITCUGST-UHFFFAOYSA-N

Data  4 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50372181   

TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50372181(CHEMBL403727)
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50372181(CHEMBL403727)
Affinity DataIC50: 165nMAssay Description:Inhibition of BACE1 in human HEK293 cells assessed as inhibition of amyloid beta 40 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50372181(CHEMBL403727)
Affinity DataIC50: 165nMAssay Description:Inhibition of human BACE1 assessed as amyloid beta 40 production in human HEK293 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50372181(CHEMBL403727)
Affinity DataIC50: 3nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50372181(CHEMBL403727)
Affinity DataIC50: 54nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50372181(CHEMBL403727)
Affinity DataIC50: 54nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCathepsin E(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50372181(CHEMBL403727)
Affinity DataKi:  24nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCathepsin E(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50372181(CHEMBL403727)
Affinity DataKi:  24nMAssay Description:Binding affinity to human cathepsin EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50372181(CHEMBL403727)
Affinity DataKi:  291nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50372181(CHEMBL403727)
Affinity DataKi:  291nMAssay Description:Binding affinity to human cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed