BDBM50370494 CHEMBL4176720

SMILES OC1CCN(Cc2ccccc2NC(=O)Nc2ccc(CCNc3ncnc4oc(c(Cl)c34)-c3ccccc3)cc2)CC1

InChI Key InChIKey=WVLFHLOAIDRNCV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50370494   

TargetAurora kinase A(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50370494(CHEMBL4176720)
Affinity DataIC50: 228nMAssay Description:Inhibition of GST-tagged human recombinant Aurora A kinase domain (123 to 401 residues) expressed in Sf9 cells after 120 mins by kinase-glo luminesce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50370494(CHEMBL4176720)
Affinity DataIC50: 79nMAssay Description:Inhibition of human recombinant full length Aurora-B (1 to 344 residues) expressed in Sf9 cells after 90 mins by kinase-glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50370494(CHEMBL4176720)
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of Aurora-A autophosphorylation at Thr288 in human HCT116 cells after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50370494(CHEMBL4176720)
Affinity DataIC50: 133nMAssay Description:Inhibition of Aurora-B autophosphorylation at Thr232 in human HCT116 cells after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed