BDBM50370067 CHEMBL1237164::US12215173, Compound Naltrindole
SMILES c1ccc2c(c1)c3c([nH]2)[C@H]4[C@@]56CCN([C@@H]([C@@]5(C3)O)Cc7c6c(c(cc7)O)O4)CC8CC8
InChI Key InChIKey=WIYUZYBFCWCCQJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 33 hits for monomerid = 50370067
Affinity DataIC50: 0.510nMAssay Description:Antagonist activity at human delta opioid receptor expressed in CHO cells assessed as reduction in SNC80-induced inhibition of forskolin stimulated c...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 0.183nMAssay Description:The assay buffers used for opioid receptor binding studies were 50 mM Tris HCl (pH 7.4) for KOR, 50 mM Tris HCl (pH 7.4) with 5 mM MgCl2 for MOR, and...More data for this Ligand-Target Pair
Affinity DataIC50: 0.720nMAssay Description:Antagonist activity at mouse delta opioid receptor-1 expressed in CHO cell membranes assessed as inhibition of DPDPE-induced [35S]GTPgammaS binding i...More data for this Ligand-Target Pair
Affinity DataKi: 0.0300nMAssay Description:Antagonist activity of compound on agonist stimulated [35S]GTP-gamma-S binding on delta-opioid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.0310nMAssay Description:Compound was evaluated for the binding affinity to opioid receptor delta using [3H]DADLE as radioligand in guinea pig brain membraneMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Displacement of [3H]Cl-DPDPE from human recombinant delta opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting met...More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rat)
University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School (Umdnj-Rwjms)
Curated by ChEMBL
University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School (Umdnj-Rwjms)
Curated by ChEMBL
Affinity DataKi: 0.220nMAssay Description:Binding affinity against Opioid receptor delta 1 from rat brain membranes using [3H]DADLEMore data for this Ligand-Target Pair
Affinity DataKi: 0.220nMAssay Description:Displacement of [3H]DADLE at delta-opioid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.457nMAssay Description:Displacement of [3H]DPDPE from human DOR expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.460nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rat)
University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School (Umdnj-Rwjms)
Curated by ChEMBL
University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School (Umdnj-Rwjms)
Curated by ChEMBL
Affinity DataKi: 0.830nMAssay Description:Displacement of [3H]DPDPE from DOR in rat brain membranes incubated for 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Displacement of [3H]DADLE from delta opioid receptor (unknown origin) expressed in HEK293T cells after 1.5 hrs by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Displacement of [3H]DADLE from delta opioid receptor (unknown origin)More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rat)
University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School (Umdnj-Rwjms)
Curated by ChEMBL
University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School (Umdnj-Rwjms)
Curated by ChEMBL
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]DPDPE from DOR in rat brain membranes incubated for 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rat)
University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School (Umdnj-Rwjms)
Curated by ChEMBL
University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School (Umdnj-Rwjms)
Curated by ChEMBL
TargetDelta-type opioid receptor(Rat)
University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School (Umdnj-Rwjms)
Curated by ChEMBL
University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School (Umdnj-Rwjms)
Curated by ChEMBL
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]-(2-D-Ala)[Tyrosy1-3,5-]-DELTORPHIN II from Sprague-Dawley rat brain membrane delta opioid receptor incubated for 45 mins by liqu...More data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Binding affinity to DOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.63nMAssay Description:Displacement of [3H]-DPDPE from mouse DOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3.80nMAssay Description:Compound was evaluated for the binding affinity to Opioid receptor mu using [3H]DAMGO as radioligand in guinea pig brain membraneMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 4.30nMAssay Description:Antagonist activity of compound on agonist stimulated [35S]GTP-gamma-S binding on mu-opioid receptorMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Guinea pig)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 4.70nMAssay Description:Antagonist activity of compound on U50,488H stimulated [35S]GTP-gamma-S binding to opioid receptor kappa 1More data for this Ligand-Target Pair
Affinity DataKi: 6.30nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Displacement of [3H]U69593 from human recombinant kappa opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting metho...More data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Displacement of [3H]U-69,593 from human KOR expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 16.6nMAssay Description:Displacement of [3H]-DAMGO from mouse MOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 27nMAssay Description:Binding affinity against Opioid receptor mu 1 from rat brain membranes using [3H]DAMGOMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 27nMAssay Description:Displacement of [3H]DAMGO at mu-opioid receptorMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Guinea pig)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 27nMAssay Description:Binding affinity against Opioid receptor kappa 1 from guinea pig brain membranes using [3H]U-69593More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Guinea pig)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 30nMAssay Description:Displacement of [3H]U-69593 at opioid receptor kappa 1More data for this Ligand-Target Pair
Affinity DataKi: 31nMAssay Description:Displacement of [3H]DAMGO from human MOR expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 31nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Guinea pig)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 333nMAssay Description:Compound was evaluated for the binding affinity to opioid receptor kappa using [3H]-EK as radioligand in guinea pig brain membraneMore data for this Ligand-Target Pair