BDBM50367220 CHEMBL4168422

SMILES COc1cc(c(F)cn1)-c1ccc(nc1)C1CCc2ccc(cc2O1)[C@@H]([C@H](C)C([O-])=O)C1CC1

InChI Key InChIKey=GTABCRSFTCTJJI-UHFFFAOYSA-M

Data  1 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50367220   

TargetFree fatty acid receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50367220(CHEMBL4168422)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GPR120 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50367220(CHEMBL4168422)
Affinity DataEC50:  5.20nMAssay Description:Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50367220(CHEMBL4168422)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human BSEP expressed in baculovirus infected Sf9 insect cell membrane vesicles assessed as reduction in ATP-dependent [3H]-taurocholic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50367220(CHEMBL4168422)
Affinity DataEC50:  243nMAssay Description:Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50367220(CHEMBL4168422)
Affinity DataEC50:  243nMAssay Description:Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50367220(CHEMBL4168422)
Affinity DataEC50: <0.200nMAssay Description:Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50367220(CHEMBL4168422)
Affinity DataEC50:  2.70nMAssay Description:Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed