BDBM50367097 CHEMBL4173799

SMILES Cc1cc(cc2c1n(C)c(=O)c1cc(F)ccc21)C(O)(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=XDFUKFMDLRMNOJ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50367097   

TargetProgesterone receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50367097(CHEMBL4173799)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity measured after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50367097(CHEMBL4173799)
Affinity DataIC50: 150nMAssay Description:Displacement of [1,2,6,7-3H]progesterone from recombinant human GST-tagged PGR LBD (678 to 933 residues) expressed in baculovirus-infected insect cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50367097(CHEMBL4173799)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at human CMX-AR expressed in HEK293 cells assessed as reduction in dihydrotestosterone-induced transactivation activity after 24 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50367097(CHEMBL4173799)
Affinity DataIC50: 2.00E+4nMAssay Description:Antagonist activity at human GAL4N-fused LXRbeta LBD expressed in HEK293 cells assessed as reduction in T0901317-induced transactivation activity aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50367097(CHEMBL4173799)
Affinity DataIC50: 2.00E+4nMAssay Description:Antagonist activity at human GAL4N-fused LXRalpha LBD expressed in HEK293 cells assessed as reduction in T0901317-induced transactivation activity af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-beta(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50367097(CHEMBL4173799)
Affinity DataIC50: 2.00E+4nMAssay Description:Antagonist activity at human RORbeta1 expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50367097(CHEMBL4173799)
Affinity DataIC50: 2.00E+4nMAssay Description:Antagonist activity at human CMX-GRalpha expressed in HEK293 cells assessed as reduction in dexamethasone-induced transactivation activity after 24 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed