BDBM50366839 CHEMBL4175583

SMILES NC(=O)c1cc2ccc(OCC(F)(F)F)cc2n1-c1cccc(CCC(O)=O)c1

InChI Key InChIKey=KXXHZMLDLNDFRT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50366839   

TargetPhospholipase A2, membrane associated(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366839(CHEMBL4175583)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human sPLA2-2A expressed in Escherichia coli BL21(DE3) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetGroup 10 secretory phospholipase A2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366839(CHEMBL4175583)
Affinity DataIC50: 740nMAssay Description:Inhibition of recombinant human sPLA2-10 expressed in Escherichia coli BL21(DE3) using HDL as substrate pretreated for 20 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetGroup 10 secretory phospholipase A2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366839(CHEMBL4175583)
Affinity DataIC50: 93nMAssay Description:Inhibition of recombinant human sPLA2-10 expressed in Escherichia coli BL21(DE3) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed