BDBM50366779 METHYLLYCACONITINE
SMILES CCN1C[C@]2(COC(=O)c3ccccc3-n3c(O)cc(C)c3O)CC[C@H](OC)[C@@]34[C@@H]5C[C@H]6[C@H](OC)[C@@H]5[C@](O)(C[C@@H]6OC)[C@](O)([C@@H](OC)[C@H]23)[C@H]14
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 50366779
Affinity DataIC50: 2.60E+3nMAssay Description:Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretionMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
The Danish University of Pharmaceutical Sciences
Curated by ChEMBL
The Danish University of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha 7More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
School of Pharmacy and Pharmacology
Curated by ChEMBL
School of Pharmacy and Pharmacology
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Binding affinity of Norditerpenoid Alkaloids at rat neuronal alpha7-type nicotinic acetylcholine receptorMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
The Danish University of Pharmaceutical Sciences
Curated by ChEMBL
The Danish University of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataIC50: 8.30nMAssay Description:Antagonist activity at human alpha-7 nAChR in tsA201 cells coexpressed with Ric3 by FMP assayMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
The Danish University of Pharmaceutical Sciences
Curated by ChEMBL
The Danish University of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataIC50: 8.30nMAssay Description:Antagonist activity at human alpha7nAChR co-expressed with human Ric3 in tsA201 cells by FMP assayMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
School of Pharmacy and Pharmacology
Curated by ChEMBL
School of Pharmacy and Pharmacology
Curated by ChEMBL
Affinity DataKi: 0.600nMAssay Description:Binding affinity against alpha7 nAChR (nicotinic acetylcholine receptor) using [3H]-MLA as a radioligand relative to alpha4-beta2More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
School of Pharmacy and Pharmacology
Curated by ChEMBL
School of Pharmacy and Pharmacology
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Binding affinity against alpha-7 nAChR (nicotinic acetylcholine receptor) using [125I]-alpha-BGT as a radioligand relative to alpha4-beta2More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
The Danish University of Pharmaceutical Sciences
Curated by ChEMBL
The Danish University of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Displacement of [3H]methyllycaconitine from human alpha-7 in tsA201 cells coexpressed with 5HT3A receptorMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
School of Pharmacy and Pharmacology
Curated by ChEMBL
School of Pharmacy and Pharmacology
Curated by ChEMBL
Affinity DataKi: 2.30nMAssay Description:Binding affinity nicotinic acetylcholine receptor alpha-7 was evaluated by its ability to inhibit [3H]methyllycaconitine ([3H]-MLA) binding to rat br...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rat)
University of Kentucky
Curated by ChEMBL
University of Kentucky
Curated by ChEMBL
Affinity DataKi: 2.30nMAssay Description:Affinity for Nicotinic acetylcholine receptor alpha4-beta2 tested by analogue-induced inhibition of [3H]NIC binding to rat striatal membranesMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
School of Pharmacy and Pharmacology
Curated by ChEMBL
School of Pharmacy and Pharmacology
Curated by ChEMBL
Affinity DataKi: 2.30nMAssay Description:Inhibitory constant against [3H]methyllycaconitine binding towards Nicotinic acetylcholine receptor alpha-7 of rat brain hippocampusMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
School of Pharmacy and Pharmacology
Curated by ChEMBL
School of Pharmacy and Pharmacology
Curated by ChEMBL
Affinity DataKi: 2.90nMAssay Description:Displacement of [125I]alpha-bungarotoxin from rat cortical membrane alpha7-nAChR after 150 mins by gamma-counting analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
School of Pharmacy and Pharmacology
Curated by ChEMBL
School of Pharmacy and Pharmacology
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in rat brain membraneMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
School of Pharmacy and Pharmacology
Curated by ChEMBL
School of Pharmacy and Pharmacology
Curated by ChEMBL
Affinity DataKi: 4.80nMAssay Description:Binding affinity towards alpha-7 neuronal nicotinic acetylcholine receptor (nAChRs) measured by using the inhibition of [3H]-MLA binding to whole bra...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
The Danish University of Pharmaceutical Sciences
Curated by ChEMBL
The Danish University of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataKi: 6.10nMAssay Description:Displacement of [3H]methyllycaconitine from alpha7 nAChR in tsA201 cells co-expressed with Ric3More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
The Danish University of Pharmaceutical Sciences
Curated by ChEMBL
The Danish University of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataKi: 7.30nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
School of Pharmacy and Pharmacology
Curated by ChEMBL
School of Pharmacy and Pharmacology
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity against alpha-7 nAChR (nicotinic acetylcholine receptor) using [3H]epibatidine as a radioligand relative to alpha4-beta2More data for this Ligand-Target Pair
Affinity DataKi: 1.30E+3nMAssay Description:Binding affinity towards alpha3-beta4 neuronal nicotinic acetylcholine receptorMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 1.46E+3nMAssay Description:Binding affinity towards alpha4-beta2 measured by using the inhibition of [3H]NIC binding to rat striatal membraneMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 1.56E+3nMAssay Description:Binding affinity for nicotinic acetylcholine receptor alpha4-beta2 was evaluated by its ability to inhibit [3H]NIC binding to rat brain membranesMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
School of Pharmacy and Pharmacology
Curated by ChEMBL
School of Pharmacy and Pharmacology
Curated by ChEMBL
Affinity DataKi: 1.56E+3nMAssay Description:Affinity for alpha-7 neuronal nicotinic acetylcholine receptor subtype determined by inhibition of [3H]-MLA binding to rat brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2; Not significantMore data for this Ligand-Target Pair