BDBM50366305 CHEBI:70328::CHEMBL445599

SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6@H](-[#6][C@]12[#6]-[#6@H](-[#6]\[#6]=[#6](\[#6])-[#6])C([#6])([#6])[C@]([#6]\[#6]=[#6](\[#6])-[#6])([#6](=O)-[#6](-[#6](=O)-c3ccc(-[#8])c(-[#8])c3)=[#6]1-[#8])[#6]2=O)-[#6](-[#6])=[#6]

InChI Key InChIKey=DOANGWFJSCDBBT-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50366305   

TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50366305(CHEMBL445599 | CHEBI:70328)
Affinity DataIC50: 300nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50366305(CHEMBL445599 | CHEBI:70328)
Affinity DataIC50: 500nMAssay Description:Inhibition of human p300 expressed in Escherichia coli incubated for 15 mins followed by [3H]acetyl-CoA/histone additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50366305(CHEMBL445599 | CHEBI:70328)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of full length His6-tagged recombinant p300 (unknown origin) expressed in baculovirus infected Sf21 cells using human histone as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50366305(CHEMBL445599 | CHEBI:70328)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of recombinant full-length His6-tagged human P300 expressed in Baculovirus-infected Sf21 cells using histone as substrate after 10 mins in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50366305(CHEMBL445599 | CHEBI:70328)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant FLAG epitope-tagged human PCAF expressed in Baculovirus-infected Sf21 cells using histone as substrate after 10 mins in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50366305(CHEMBL445599 | CHEBI:70328)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of recombinant human full-length His6-tagged p300 expressed in baculovirus infected Sf21 insect cells using [3H]acetylCoA as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
European Biomedical Research Institute of Salerno (Ebris)

Curated by ChEMBL
LigandPNGBDBM50366305(CHEMBL445599 | CHEBI:70328)
Affinity DataIC50: 1.01E+5nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated relaxation of supercoiled pSG483 DNA after 30 mins by ethidium bromide staining based agarose gel e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
European Biomedical Research Institute of Salerno (Ebris)

Curated by ChEMBL
LigandPNGBDBM50366305(CHEMBL445599 | CHEBI:70328)
Affinity DataIC50: 1.01E+5nMAssay Description:Inhibition of human topoisomerase 2beta-mediated relaxation of supercoiled pSG483 DNA after 30 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed