BDBM50365710 CHEMBL1955989

SMILES FC(F)(F)c1ccccc1-c1ccc2nc(C=CC3CCCCC3)[nH]c2c1

InChI Key InChIKey=UJDYXOAGLLGCSW-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50365710   

LigandPNGBDBM50365710(CHEMBL1955989)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human TRPM8 by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50365710(CHEMBL1955989)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at rat TRPM8 by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50365710(CHEMBL1955989)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of recombinant CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50365710(CHEMBL1955989)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of recombinant CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50365710(CHEMBL1955989)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50365710(CHEMBL1955989)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50365710(CHEMBL1955989)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50365710(CHEMBL1955989)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50365710(CHEMBL1955989)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetTransient receptor potential M8 protein(Dog)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50365710(CHEMBL1955989)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed