BDBM50365242 CHEMBL1956268::US9238653, Table 5, Compound 45

SMILES CC(C)c1nc2nc(C)cc(Nc3ccc(cc3)C(F)(F)F)n2n1

InChI Key InChIKey=VYVPDPXTAPGXSK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50365242   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University Of Texas

US Patent
LigandPNGBDBM50365242(CHEMBL1956268 | US9238653, Table 5, Compound 45)
Affinity DataIC50: 110nMpH: 8.0Assay Description:For studying inhibition of Plasmodium or human DHODH enzyme, two assays that are in routine use are described, for example, in Baldwin, et al. (2002)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
Go to US Patent

LigandPNGBDBM50365242(CHEMBL1956268 | US9238653, Table 5, Compound 45)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed