BDBM50365231 CHEMBL1738786::US9238653, Table 5, Compound 7

SMILES Cc1cc(n2c(n1)nc(n2)C(C)(F)F)Nc3ccc(cc3)C(F)(F)F

InChI Key InChIKey=CUCVTDOXQYMYKL-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50365231   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University Of Texas

US Patent
LigandPNGBDBM50365231(CHEMBL1738786 | US9238653, Table 5, Compound 7)
Affinity DataIC50: 38nMpH: 8.0Assay Description:For studying inhibition of Plasmodium or human DHODH enzyme, two assays that are in routine use are described, for example, in Baldwin, et al. (2002)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rat)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50365231(CHEMBL1738786 | US9238653, Table 5, Compound 7)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of rat DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroorot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50365231(CHEMBL1738786 | US9238653, Table 5, Compound 7)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of mouse DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50365231(CHEMBL1738786 | US9238653, Table 5, Compound 7)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50365231(CHEMBL1738786 | US9238653, Table 5, Compound 7)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50365231(CHEMBL1738786 | US9238653, Table 5, Compound 7)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50365231(CHEMBL1738786 | US9238653, Table 5, Compound 7)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Blood fluke)
University of Turin (Unito)

Curated by ChEMBL
LigandPNGBDBM50365231(CHEMBL1738786 | US9238653, Table 5, Compound 7)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of Schistosoma mansoni DHODHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed