BDBM50364031 CHEMBL1950434

SMILES COc1cc(\C=C2/CCCN3C2=NO[C@]3(CO)c2ccc(F)cc2)ccc1-n1cnc(C)c1

InChI Key InChIKey=ADVSCLOHXCBWQC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50364031   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50364031(CHEMBL1950434)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human ERG by cell based voltage clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50364031(CHEMBL1950434)
Affinity DataIC50: 29nMAssay Description:Inhibition of gamma-secretase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50364031(CHEMBL1950434)
Affinity DataIC50: 29nMAssay Description:Modulation of gamma-secretase expressed in HEK293 cells co-expressing APPsw-lon assessed as reduction of amyloid-beta-42 level by sandwich immunoassa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50364031(CHEMBL1950434)
Affinity DataIC50: 29nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed