BDBM50363655 CHEMBL1945236

SMILES NC(=N)c1ccc(\C=C2\N=C(OC2=O)c2ccccc2)cc1

InChI Key InChIKey=JBHISGPWLXASFE-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50363655   

TargetTissue-type plasminogen activator(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50363655(CHEMBL1945236)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 mins by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50363655(CHEMBL1945236)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50363655(CHEMBL1945236)
Affinity DataIC50: 200nMAssay Description:Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 mins by spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50363655(CHEMBL1945236)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50363655(CHEMBL1945236)
Affinity DataIC50: 5.61E+4nMAssay Description:Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-pNA-HCl as substrate measured for 5 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50363655(CHEMBL1945236)
Affinity DataIC50: 6.47E+3nMAssay Description:Inhibition of purified human factor 10a using Suc-Ile-Glu(gammaPip)-GlyArg-pNa-HCl as substrate measured for 5 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
University of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50363655(CHEMBL1945236)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of human plasma kallikrein using D-Pro-Phe-Arg-pNA-2HCl as substrate measured for 5 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50363655(CHEMBL1945236)
Affinity DataIC50: 8.67E+3nMAssay Description:Inhibition of human uPA using pyro-Glu-Gly-Arg-pNA as substrate assessed as para-nitroaniline release from substrate measured for 5 mins by spectroph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50363655(CHEMBL1945236)
Affinity DataIC50: 6.85E+4nMAssay Description:Inhibition of recombinant human tPA using H-D-Ile-Pro-L-Arg-pNA-2HCl as substrate measured for 5 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50363655(CHEMBL1945236)
Affinity DataIC50: 340nMAssay Description:Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-pNA-HCl as substrate measured for 5 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed