BDBM50362779 CHEMBL1940181::US9126931, 346

SMILES Cc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCC(CC1)N1CCOCC1

InChI Key InChIKey=GXWLTJGZFHXMSX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50362779   

TargetALK tyrosine kinase receptor(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50362779(CHEMBL1940181 | US9126931, 346)
Affinity DataIC50: 2.61nMAssay Description:ALK-inhibiting activity was measured by following an activity of inhibiting phosphorylation by biotinylated peptide (EGPWLEEEEEAYGWMDF). For the dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362779(CHEMBL1940181 | US9126931, 346)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MET using Bio-HER2tide as substrate by TR-FRET assay in presence of 50 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362779(CHEMBL1940181 | US9126931, 346)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of KIT using Bio-HER2tide as substrate by TR-FRET assay in presence of 50 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362779(CHEMBL1940181 | US9126931, 346)
Affinity DataIC50: 186nMAssay Description:Inhibition of KDR using Bio-Gastrintide as substrate by TR-FRET assay in presence of 50 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50362779(CHEMBL1940181 | US9126931, 346)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed