BDBM50361653 CHEMBL1940245

SMILES CC(C)n1cc(C(=O)c2cncc(N[C@@H]3CCC[C@@H]3c3ccccc3)n2)c2c(N)ncnc12

InChI Key InChIKey=DINCQWMGMYFLCH-UHFFFAOYSA-N

Data  2 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50361653   

Target3-phosphoinositide-dependent protein kinase 1(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50361653(CHEMBL1940245)Copy SMILESCopy InChI

Affinity DataKi:  2nMAssay Description:Inhibition of PDK1-mediated AKT1 phosphorylation at T308 in human H460 cells after 2 hrs by ELISAMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/22/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Mouse)
Pfizer

Curated by ChEMBL

LigandBDBM50361653(CHEMBL1940245)Copy SMILESCopy InChI

Affinity DataKi:  130nMAssay Description:Inhibition of mouse PI3Kalpha after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/22/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL