BDBM50361171 CHEMBL4175555

SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCC(CC2)C(=O)Nc2ccc(\C=C\C(=O)NO)cc2)n1

InChI Key InChIKey=LUTGPKYBTPTJKM-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50361171   

TargetTyrosine-protein kinase JAK2(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50361171(CHEMBL4175555)
Affinity DataIC50: 8nMAssay Description:Inhibition of JAK2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50361171(CHEMBL4175555)
Affinity DataIC50: 46nMAssay Description:Inhibition of full length human recombinant HDAC6 expressed in Baculovirus infected Sf9 cells using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50361171(CHEMBL4175555)
Affinity DataIC50: 359nMAssay Description:Inhibition of JAK1 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50361171(CHEMBL4175555)
Affinity DataIC50: 46nMAssay Description:Inhibition of TYK2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50361171(CHEMBL4175555)
Affinity DataIC50: 6.07E+3nMAssay Description:Inhibition of full length recombinant C-terminal His tagged human HDAC8 expressed in Baculovirus infected Sf9 cells using Ac-Leu-Gly-Lys(Tfa)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50361171(CHEMBL4175555)
Affinity DataIC50: 250nMAssay Description:Inhibition of full length human recombinant HDAC1 expressed in baculovirus expression system using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50361171(CHEMBL4175555)
Affinity DataIC50: 121nMAssay Description:Inhibition of JAK3 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetNuclear receptor corepressor 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50361171(CHEMBL4175555)
Affinity DataIC50: 234nMAssay Description:Inhibition of human recombinant HDAC3/GST-tagged NCOR1 (397 to 503 residues) co-expressed in insect cells using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50361171(CHEMBL4175555)
Affinity DataIC50: 7.47E+3nMAssay Description:Inhibition of recombinant HDAC2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed